Loss of MicroRNA-137 Impairs the Homeostasis of Potassium in Neurons via KCC2
Ting‐Wei Mi, Xiaowen Sun, Zhimeng Wang, Yingying Wang, Xuan‐Cheng He, Cong Liu, Shuang-Feng Zhang, Hong‐Zhen Du, Chang‐Mei Liu, Zhao‐Qian Teng
Abstract
knockout mouse model, and provided evidence that loss of miR-137 resulted in impaired homeostasis of potassium in mouse hippocampal neurons. KCC2, a potassium-chloride co-transporter, was a direct downstream target of miR-137. The KCC2 specific antagonist VU0240551 could balance the current of potassium in miR-137 knockout neurons, and knockdown of KCC2 could ameliorate anxiety-like behavior in MIR137 cKO mice. These data suggest that KCC2 antagonists or knockdown might be beneficial to neuropsychiatric disorders due to the deficiency of miR-137.
Topics & Concepts
microRNAHomeostasisCell biologyNeurosciencePotassiumBioinformaticsCancer researchMedicineChemistryBiologyGeneBiochemistryOrganic chemistryMicroRNA in disease regulationCancer-related molecular mechanisms researchCircular RNAs in diseases