Structural Insights into the Atomistic Mechanisms of Uric Acid Recognition and Translocation of Human Urate Anion Transporter 1
Zean Zhao, Jiang Yu, Lu Li, Yanyu Chen, Yongmei Li, Qunsheng Lan, Ting Wu, Cuiting Lin, Ying Cao, Kutty Selva Nandakumar, Pingzheng Zhou, Yuanxin Tian, Jianxin Pang
Abstract
: W357-F365 in TMD7, P484-R487 in TMD11, and residues F241, H245, and R477 were found to be critical for the translocation and recognition of uric acid.
Topics & Concepts
Uric acidHyperuricemiaTransporterHomology modelingChemistryBiochemistryDocking (animal)Chromosomal translocationMutantGeneEnzymeMedicineNursingGout, Hyperuricemia, Uric AcidAlcohol Consumption and Health Effects