PDE4 inhibition alleviates HMGB1/C1q/C3-mediated excessive phagocytic pruning of synapses by microglia and depressive-like behaviors in mice

Qian Zhao, Chunyuan Zeng, Fulan Luo, Zihong Xian, Huizhen Wen, Xingxing Tu, Ri‐Fang Yang, Yijun Sun, Xiao Mei Zheng, Jiangping Xu, Haitao Wang

2025Brain Behavior and Immunity15 citationsDOI

Topics & Concepts

Synaptic pruningMicrogliaHMGB1PruningNeuroscienceMedicinePharmacologyImmunologyPsychologyInflammationBiologyAgronomyNeuroinflammation and Neurodegeneration MechanismsAdenosine and Purinergic SignalingAdvanced Glycation End Products research