Regulation of P450 TleB catalytic flow for the synthesis of sulfur-containing indole alkaloids by substrate structure-directed strategy and protein engineering
Xinying Ge, Yan Long, Jun Wang, Bo Gu, Zixuan Yang, Yinyin Feng, Shuo Zheng, Yingying Li, Wupeng Yan, Heng Song
Topics & Concepts
ChemistryCatalysisSubstrate (aquarium)Indole testSelectivityCombinatorial chemistryHydrogen bondProtein engineeringMonooxygenaseStereochemistryCytochrome P450MoleculeOrganic chemistryEnzymeGeologyOceanographyPharmacogenetics and Drug MetabolismSynthesis and Catalytic ReactionsCatalytic C–H Functionalization Methods