Comprehensive review of plant-derived triterpenoid types, structures and cytotoxicity: an update from 2015 to 2024
Olagoke Zacchaeus Olatunde, Jianping Yong, Danian Tian, Can‐Zhong Lu
Abstract
. Some triterpenoids have been approved for clinical use for the treatment of cancer, while other potent compounds are currently being evaluated in clinical trials. In this work, we provide a comprehensive overview of the types, structures, and cytotoxicity of plant-derived triterpenoids reported from 2015 to 2024. We also propose constructive strategies for their structural modifications based on their structure-activity relationships (SARs) in the hope of developing new anticancer drugs.
Topics & Concepts
CytotoxicityTriterpenoidComputational biologyCancer cell linesBiologyCancerIn vitroTraditional medicineMedicineCancer cellBiochemistryGeneticsNatural product bioactivities and synthesisPhytochemical compounds biological activitiesPlant biochemistry and biosynthesis