Arachidonic acid induces ferroptosis in hepatocellular carcinoma via the SIRT5-ACSL4/LPCAT3/ALOX15 axis, leading to lipid peroxidation and mitochondrial dysfunction
Peisen Xue, Jingting Zhang, Zhibing Wang, Ling Wu, Jincheng Tang, Renyi Yang, Wenhui Gao, Puhua Zeng
Topics & Concepts
Arachidonic acidChemistryHepatocellular carcinomaGPX4Lipid peroxidationCancer researchLipid signalingMitochondrionOxidative stressBiochemistryPharmacologyCell biologyReactive oxygen speciesApoptosisCYP2C8Lipid accumulationOxidative damageOxidative phosphorylationProgrammed cell deathFerroptosis and cancer prognosisCancer, Lipids, and MetabolismClusterin in disease pathology