1,25-Dihydroxyvitamin D Deficiency Accelerates Aging-related Osteoarthritis via Downregulation of Sirt1 in Mice
Jie Chen, Jiao Zhang, Jie Li, Ran Qin, Na Lü, David Goltzman, Dengshun Miao, Renlei Yang
Abstract
via VDR-mediated gene transcription, plays a key role in preventing the onset of aging-related knee OA in mouse models by up-regulating Sirt1, an aging-related gene that promotes articular chondrocyte proliferation and extracellular matrix protein synthesis, and inhibits senescence and SASP.
Topics & Concepts
ChondrocyteCartilageOsteoarthritisCalcitriol receptorSenescencePhenotypeInternal medicineEndocrinologyMesenchymal stem cellKnockout mouseDownregulation and upregulationAggrecanChemistryCancer researchVitamin D and neurologyMedicineCell biologyBiologyPathologyGeneBiochemistryArticular cartilageAnatomyReceptorAlternative medicineVitamin D Research StudiesAdipokines, Inflammation, and Metabolic DiseasesExercise and Physiological Responses