Estradiol treatment or modest exercise improves hepatic health and mitochondrial outcomes in female mice following ovariectomy
Kelly N. Z. Fuller, Colin S. McCoin, Alex Von Schulze, Claire J. Houchen, Michael Choi, John P. Thyfault
Abstract
OVX induces hepatic steatosis in sedentary mice which can be prevented by modest physical activity (VWR) and/or estradiol treatment. Estrogen impacts hepatic mitochondrial coupling in a substrate-specific manner. OVX mice have impaired fecal bile acid excretion, which was rescued with estradiol treatment.
Topics & Concepts
Internal medicineEndocrinologySteatosisEstrogenMitochondrial biogenesisMedicineFatty liverBiologyMitochondrionCell biologyDiseaseAdipose Tissue and MetabolismStress Responses and CortisolDietary Effects on Health