Extracellular vesicles from adipose stromal cells combined with a thermoresponsive hydrogel prevent esophageal stricture after extensive endoscopic submucosal dissection in a porcine model
Elise Coffin, Alice Grangier, Guillaume Perrod, Max Piffoux, Iris Marangon, Imane Boucenna, Arthur Berger, Leila M’harzi, Jessica Assouline, Thierry Lecomte, Anna Chipont, Coralie L. Guérin, Florence Gazeau, Claire Wilhelm, Christophe Cellier, Olivier Clémеnt, Amanda Silva, Gabriel Rahmi
Abstract
were observed for the EV + gel group. In summary, the application of EVs + gel after extended esophageal endoscopic resection succeeded in preventing stricture formation with an anti-fibrotic effect. This nano-therapy may be of interest to tackle an unmet medical need considering that esophageal stricture is the most challenging delayed complication after extended superficial cancer resection by endoscopy.
Topics & Concepts
Esophageal strictureStromal cellAdipose tissueExtracellular vesiclesEndoscopic submucosal dissectionExtracellularMesenchymal stem cellExtracellular matrixBiomedical engineeringCell biologyPathologyChemistryMaterials scienceBiophysicsAnatomyMedicineEsophagusSurgeryBiologyBiochemistryTissue Engineering and Regenerative MedicineEsophageal and GI PathologyTracheal and airway disorders