Discovery of novel dual c-Met/HDAC inhibitors as a promising strategy for cancer therapy
Hao Hu, Fei Chen, Yuhong Dong, Yajing Liu, Ping Gong
Topics & Concepts
ChemistryCabozantinibVorinostatHydroxamic acidHDAC1LinkerIC50C-MetPharmacologyCancer researchCell cycle checkpointApoptosisCombinatorial chemistryHistone deacetylaseStereochemistryIn vitroCell cycleBiochemistryHistoneReceptorComputer scienceBiologyMedicineOperating systemGeneVEGF receptorsHepatocyte growth factorHistone Deacetylase Inhibitors ResearchPeptidase Inhibition and AnalysisMultiple Myeloma Research and Treatments