Decyanative Heteroarylations of Glycine Derivatives
Chenxing Zhou, Dongsheng Ji, Xuxia Wang, Caixia Yang, Pengxin Zhou, Congde Huo
Abstract
Amino acids and aromatic nitrogen heterocycles are widely used in pharmaceuticals. Herein, we present an effective visible-light-driven thiobenzoic acid (TBA)-catalyzed decyanative C(sp3)-H heteroarylation of glycine derivatives. This process occurs under mild and straightforward conditions, affording a range of valuable yet challenging-to-obtain α-heteroaryl amino acid derivatives. Moreover, this organocatalytic C(sp3)-C(sp2) bond formation reaction is applicable to the late-stage modification of various short peptides.
Topics & Concepts
ChemistryGlycineAmino acidCombinatorial chemistryCatalysisOrganic chemistryBiochemistrySulfur-Based Synthesis TechniquesRadical Photochemical ReactionsCatalytic C–H Functionalization Methods