Organosilica nanoparticles containing sodium borocaptate (BSH) provide new prospects for boron neutron capture therapy (BNCT): efficient cellular uptake and enhanced BNCT efficacy
Mathilde Laird, Kotaro Matsumoto, Yuya Higashi, Aoi Komatsu, Art Raitano, Kendall Morrison, Minoru Suzuki, Fuyuhiko Tamanoi
Abstract
the nanocarrier. Overall, these results demonstrate the critical role of the nanocarrier in BSH internalization and the enhanced BNCT efficacy of the BSH-BPMO compared with BSH and BPA, two drugs used in BNCT clinical trials.
Topics & Concepts
NanocarriersNeutron captureRadiochemistryBoronNanoparticleChemistryMaterials scienceNanotechnologyOrganic chemistryBoron Compounds in ChemistryBoron and Carbon Nanomaterials ResearchNuclear Physics and Applications