Aqueous Electrochemical Synthesis of 5-Trifluoromethyluracil in Batch and Continuous Flow
Ruoqu Gong, Yicheng Zhou, Dandan Sui, Yang Chen, Wenbo Chen
Abstract
Without the use of chemical oxidants and metal catalysts, an aqueous electrochemical synthesis of 5-trifluoromethyluracil in batch and continuous flow was reported. The green and economically friendly approach employing commercially available CF 3 SO 2 Na as a CF 3 source and cheap (NH 4 ) 2 SO 4 as a supporting electrolyte afforded the 5-trifluoromethyluracil in 10 g scale in batch electrolysis. The continuous flow-electrolysis technique was employed to further facilitate the scale-up synthesis of 5-trifluoromethyluracil.
Topics & Concepts
ElectrolysisContinuous flowElectrochemistryAqueous solutionContinuous reactorFlow chemistryElectrolyteBatch processingBatch reactorChemistryCatalysisChemical engineeringProcess engineeringOrganic chemistryElectrodeComputer scienceBiochemical engineeringEngineeringPhysical chemistryProgramming languageFluorine in Organic ChemistryChemical Synthesis and AnalysisInnovative Microfluidic and Catalytic Techniques Innovation