m6A Modification in Mammalian Nervous System Development, Functions, Disorders, and Injuries
Jun Yu, Yuanchu She, Sheng‐Jian Ji
Abstract
N 6 -methyladenosine (m 6 A) modification, as the most prevalent internal modification on mRNA, has been implicated in many biological processes through regulating mRNA metabolism. Given that m 6 A modification is highly enriched in the mammalian brain, this dynamic modification provides a crucial new layer of epitranscriptomic regulation of the nervous system. Here, in this review, we summarize the recent progress on studies of m 6 A modification in the mammalian nervous system ranging from neuronal development to basic and advanced brain functions. We also highlight the detailed underlying mechanisms in each process mediated by m 6 A writers, erasers, and readers. Besides, the involvement of dysregulated m 6 A modification in neurological disorders and injuries is discussed as well.