Benzotetramisole catalyzed kinetic resolution of 2<i>H</i>-azirines
Qiupeng Peng, Donghui Guo, Bei Zhang, Lala Liu, Jian Wang
Abstract
An unprecedented benzotetramisole (BTM)-catalyzed kinetic resolution for the efficient synthesis of chiral 2H-azirines is described. This protocol provides two chiral isomers in one step with broad scope, good yield and high enantioselectivity. In addition, the optically pure 2H-azirine products have proven to be useful building blocks for further synthetic transformations.
Topics & Concepts
CatalysisKinetic resolutionKinetic energyChemistryStereochemistryOrganic chemistryPhysicsEnantioselective synthesisQuantum mechanicsSynthesis and Catalytic ReactionsAsymmetric Hydrogenation and CatalysisAsymmetric Synthesis and Catalysis