Short Synthesis of Molnupiravir (EIDD-2801) <i>via</i> a Thionated Uridine Intermediate
Raghunath Dey, Sourav Nayak, Parthasarathi Das, Somnath Yadav
Abstract
Molnupiravir (MK-4482, EIDD-2801) is an experimental drug that has been demonstrated to be effective for the treatment of COVID-19 in human clinical trials. Herein, we report a concise synthesis of the drug via a novel thionated derivative that relies on one-pot methodologies, thus decreasing the number of purification steps required. This route provides the drug in an overall 62% yield and >99% purity and uses cheap and readily available bulk chemicals, thereby providing an affordable synthesis of the drug for cheaper and wider global accessibility.
Topics & Concepts
Yield (engineering)Combinatorial chemistryDrugDerivative (finance)ChemistryUridineComputer scienceNanotechnologyPharmacologyMedicineMaterials scienceBiochemistryRNABusinessFinanceMetallurgyGeneCancer therapeutics and mechanismsHIV/AIDS drug development and treatmentClick Chemistry and Applications