Pediatric glioblastoma target-specific efficient delivery of gemcitabine across the blood–brain barrier <i>via</i> carbon nitride dots
Piumi Y. Liyanage, Yiqun Zhou, Abdulrahman O. Al‐Youbi, Abdulaziz S. Bashammakh, M.S. El-Shahawi, Steven Vanni, Regina M. Graham, Roger M. Leblanc
Abstract
allowed the achievement of selective targeting and prominent anti-cancer activity at a 100-fold lower concentration of 10 nM. Furthermore, both conjugates were capable of effectively damaging several other brain tumor cells, which were not well responsive towards the single treatment of GM. The capability of BBB penetration of the conjugates was observed using a zebrafish model, which confirms the CNDs' competence as an excellent nanocarrier to the CNS.
Topics & Concepts
NanocarriersBlood–brain barrierDrug deliveryGemcitabineMaterials scienceNanotechnologyGlioblastomaDrugMedicineCancer researchPharmacologyInternal medicineChemotherapyCentral nervous systemCarbon and Quantum Dots ApplicationsGraphene and Nanomaterials ApplicationsGraphene research and applications