Intratumoral Fibrosis in Facilitating Renal Cancer Aggressiveness: Underlying Mechanisms and Promising Targets
Chao Hu, Yufeng Zhao, Xuanchuan Wang, Tongyu Zhu
Abstract
Intratumoral fibrosis is a histologic manifestation of fibrotic tumor stroma. The interaction between cancer cells and fibrotic stroma is intricate and reciprocal, involving dysregulations from multiple biological processes. Different components of tumor stroma are implicated via distinct manners. In the kidney, intratumoral fibrosis is frequently observed in renal cell carcinoma (RCC). However, the underlying mechanisms remain largely unclear. In this review, we recapitulate evidence demonstrating how fibrotic stroma interacts with cancer cells and mechanisms shared between RCC tumorigenesis and renal fibrogenesis, providing promising targets for future studies.
Topics & Concepts
StromaFibrosisCarcinogenesisCancerRenal cell carcinomaCancer researchPathologyCancer cellBiologyKidneyCancer-Associated FibroblastsTumor microenvironmentMedicineTumor cellsImmunohistochemistryEndocrinologyGeneticsMedical Imaging and Pathology StudiesRenal cell carcinoma treatmentCancer Diagnosis and Treatment