Tracing Foodborne Botulism Events Caused by Clostridium botulinum in Xinjiang Province, China, Using a Core Genome Sequence Typing Scheme
Xin Ma, Kexin Li, Fang Li, Jing Su, Weiwei Meng, Yanming Sun, Hui Sun, Jiazheng Sun, Yonghe Yuan, Yujia Lin, Songnian Hu, Xuefang Xu, Zilong He
Abstract
In this study, we analyzed 59 foodborne botulism (FB)-related strains isolated in Xinjiang Province, China. Our findings not only reveal the group classification, neurotoxin locus organization, antibiotic resistance and virulence factors of these strains but also establish a set of core gene markers for tracing foodborne botulism events, which was verified using published genomes. These findings indicate that these gene markers might be used as a potential tracing tool for FB events caused by C. botulinum group I strains, which have relatively stable genomic components.
Topics & Concepts
BotulismClostridium botulinumTypingWhole genome sequencingSequence (biology)BiologyChinaTracingComputational biologyGeneticsGeographyGenomeGeneComputer scienceToxinOperating systemArchaeologyBotulinum Toxin and Related Neurological DisordersHereditary Neurological DisordersPlant-based Medicinal Research