<i>In Vitro</i> Time-Kill Studies of Trimethoprim/Sulfamethoxazole against Stenotrophomonas maltophilia versus Escherichia coli Using Cation-Adjusted Mueller-Hinton Broth and ISO-Sensitest Broth
Maxwell J. Lasko, Matthew Gethers, Jennifer L. Tabor-Rennie, David P. Nicolau, Joseph L. Kuti
Abstract
Trimethoprim/sulfamethoxazole (TMP/SMZ) is considered the treatment of choice for infections caused by Stenotrophomonas maltophilia , but limited pharmacodynamic data are available to support current susceptibility breakpoints or guide optimal dosing. Time-kill studies using a TMP/SMZ concentration of 4/40 μg/mL were conducted to compare 4 S. maltophilia with 4 Escherichia coli isolates having the same MICs (0.25/4.75 to 4/76 μg/mL) in cation-adjusted Mueller-Hinton broth (CAMHB) and ISO-Sensitest broth (ISO broth).
Topics & Concepts
SulfamethoxazoleStenotrophomonas maltophiliaTrimethoprimMicrobiologyEscherichia coliChemistryEnterobacteriaceaeBiologyBacteriaPseudomonas aeruginosaAntibioticsBiochemistryGeneGeneticsInfections and bacterial resistanceBlood disorders and treatmentsAntibiotic Resistance in Bacteria