Progress in Organ Bioprinting for Regenerative Medicine
X. Sheldon Wang, Di Zhang, Yogendra Pratap Singh, Miji Yeo, Guotao Deng, Jiaqi Lai, Fei Chen, İbrahim T. Özbolat, Yin Yu
Abstract
Organ damage or failure arising from injury, disease, and aging poses challenges due to the body's limited regenerative capabilities. Organ transplantation presents the issues of donor shortages and immune rejection risks, necessitating innovative solutions. The three-dimensional (3D) bioprinting of organs on demand offers promise in tissue engineering and regenerative medicine. In this review, we explore the state-of-the-art bioprinting technologies, with a focus on bioink and cell type selections. We follow with discussions on advances in the bioprinting of solid organs, such as the heart, liver, kidney, and pancreas, highlighting the importance of vascularization and cell integration. Finally, we provide insights into key challenges and future directions in the context of the clinical translation of bioprinted organs and their large-scale production.