Discovery of pyrazolones as novel carboxylesterase 2 inhibitors that potently inhibit the adipogenesis in cells
Xing‐Kai Qian, Jing Zhang, Pei‐Fang Song, Yi-Su Zhao, Hongying Ma, Qiang Jin, Dandan Wang, Xiao‐Qing Guan, Shi-Yang Li, Xiaoze Bao, Li‐Wei Zou
Topics & Concepts
PyrazolonesChemistryCarboxylesteraseProdrugIC50EnzymeAdipogenesisPyrazoloneBiochemistryLead compoundStructure–activity relationshipIn vitroStereochemistryMedicinal chemistryCholinesterase and Neurodegenerative DiseasesComputational Drug Discovery MethodsEnzyme function and inhibition