3-(Bromoacetyl)coumarins: unraveling their synthesis, chemistry, and applications
Moaz M. Abdou, Ahmed Abu‐Rayyan, Ahmed G. Bedir, Sherif A. Abdel‐Fattah, A. M. A. Omar, Abdullah Ali Ahmed, El‐Sayed I. El‐Desoky, Eslam A. Ghaith
Abstract
This review emphasizes recent developments in synthetic routes of 3-(bromoacetyl)coumarin derivatives. Also, chemical reactions of 3-(bromoacetyl)coumarins as versatile building blocks in the preparation of critical polyfunctionalized heterocyclic systems and other industrially significant scaffolds are described. Recent advances of 3-(bromoacetyl)coumarins as attractive starting points towards a wide scale of five and six-membered heterocyclic systems such as thiophenes, imidazoles, pyrazoles, thiazoles, triazoles, pyrans, pyridines, thiadiazins as well as fused heterocyclic systems have been reported. Additionally, this review covers a wide range of analytical chemistry, fluorescent sensors, and biological applications of these moieties, covering the literature till May 2021.