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Design, synthesis and biological evaluation of coumarin linked 1,2,4-oxadiazoles as selective carbonic anhydrase IX and XII inhibitors

Pavitra S. Thacker, Andrea Angeli, Omkar S. Argulwar, Prerna L. Tiwari, Mohammed Arifuddin, Claudiu T. Supuran

2020Bioorganic Chemistry25 citationsDOI

Topics & Concepts

ChemistryCoumarinCarbonic anhydraseAcetazolamideStereochemistryLead compoundGene isoformCarbonic anhydrase IIEnzymeCombinatorial chemistryIn vitroBiochemistryOrganic chemistryAnesthesiaMedicineGeneEnzyme function and inhibitionChemical Reactions and MechanismsPhenothiazines and Benzothiazines Synthesis and Activities
Design, synthesis and biological evaluation of coumarin linked 1,2,4-oxadiazoles as selective carbonic anhydrase IX and XII inhibitors | Litcius