Multiple myeloma: the (r)evolution of current therapy and a glance into future
Annamaria Gullà, Kenneth C. Anderson
Abstract
Over the past 20 years, the regulatory approval of several novel agents to treat multiple myeloma (MM) has prolonged median patient survival from 3 to 8-10 years. Increased understanding of MM biology has translated to advances in diagnosis, prognosis, and response assessment, as well as informed the development of targeted and immune agents. Here we provide an overview of the recent progress in MM, and highlight research areas of greatest promise to further improve patient outcome in the future.
Topics & Concepts
Multiple myelomaMedicineIntensive care medicineOncologyMedical physicsInternal medicineMultiple Myeloma Research and TreatmentsProtein Degradation and InhibitorsUbiquitin and proteasome pathways