An acetyltransferase controls the metabolic flux in rubromycin polyketide biosynthesis by direct modulation of redox tailoring enzymes
Marina Toplak, Adelheid Nagel, Britta Frensch, Thorsten Lechtenberg, Robin Teufel
Abstract
Characterization of the acetyltransferase GrhJ reveals the surprising acetylation of flavoenzyme GrhO6 in rubromycin polyketide biosynthesis, showcasing a novel principle for the enzymatic regulation of secondary metabolic pathways.
Topics & Concepts
PolyketideBiosynthesisPharmacophoreEnzymeBiochemistryNatural productMonooxygenaseAcetyltransferaseChemistrySynthetic biologyBiologyGeneComputational biologyCytochrome P450AcetylationMicrobial Natural Products and BiosynthesisGenomics and Phylogenetic StudiesMicrobial Metabolism and Applications