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Supramolecular and biomacromolecular enhancement of metal-free magnetic resonance imaging contrast agents

Hamilton Lee, Arezoo Shahrivarkevishahi, Jenica L. Lumata, Michael A. Luzuriaga, Laurel M. Hagge, Candace Benjamin, Olivia R. Brohlin, Christopher Parish, Hamid R. Firouzi, Steven O. Nielsen, Lloyd Lumata, Jeremiah J. Gassensmith

2020Chemical Science60 citationsDOIOpen Access PDF

Abstract

Supramolecular/macromolecular organic radical contrast agents (smORCAs) overcome many of the limitations of nitroxide radicals for use in magnetic resonance imaging <italic>in vivo</italic> like poor stability and weak contrast.

Topics & Concepts

Supramolecular chemistryNitroxide mediated radical polymerizationMagnetic resonance imagingContrast (vision)RadicalMacromoleculeNuclear magnetic resonanceContrast enhancementChemistryMaterials scienceNanotechnologyMoleculeMedicineRadiologyOrganic chemistryPolymerPhysicsOpticsBiochemistryPolymerizationRadical polymerizationLanthanide and Transition Metal ComplexesElectron Spin Resonance StudiesMagnetism in coordination complexes
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