Persistence of mature dendritic cells, T <sub>H</sub> 2A, and Tc2 cells characterize clinically resolved atopic dermatitis under IL-4Rα blockade
Christine Bangert, Katharina Rindler, Thomas Krausgruber, Natalia Alkon, Felix M. Thaler, Harald Kurz, Tanya Ayub, Denis Demirtas, Nikolaus Fortelny, Vera Vorstandlechner, Wolfgang Bauer, Tamara Quint, Michael Mildner, Constanze Jonak, Adelheid Elbe‐Bürger, Johannes Griss, Christoph Bock, Patrick M. Brunner
Abstract
expression, suggesting that these cells are key responders to the AD-typical epidermal alarmins IL-25, IL-33, and TSLP, respectively. We thus identified disease-linked immune cell populations in resolved AD indicative of a persisting disease memory, facilitating a rapid response system of epidermal-dermal cross-talk between keratinocytes, dendritic cells, and T cells. This observation may help to explain the disease recurrence upon termination of immunosuppressive treatments in AD, and it identifies potential disease memory-linked cell types that may be targeted to achieve a more sustained therapeutic response.