MAPK-ERK is a central pathway in T-cell acute lymphoblastic leukemia that drives steroid resistance
Jordy C.G. van der Zwet, Jessica G. C. A. M. Buijs-Gladdines, Valentina Cordo’, Donna O. Debets, Willem K. Smits, Zhongli Chen, Jelle Dylus, Guido J.R. Zaman, Maarten Altelaar, Koichi Oshima, Beat Bornhäuser, Jean‐Pierre Bourquin, Jan Cools, Adolfo A. Ferrando, Josef Vormoor, Rob Pieters, Britta Vormoor, Jules P.P. Meijerink
Topics & Concepts
MAPK/ERK pathwayCancer researchMEK inhibitorInterleukin-7 receptorSelumetinibPhosphorylationSignal transductionBiologyInternal medicineEndocrinologyMedicineCell biologyImmunologyT cellIL-2 receptorImmune systemAcute Lymphoblastic Leukemia researchCell death mechanisms and regulationCAR-T cell therapy research