Copper-catalyzed tandem phosphorylative allenylation/cyclization of 1-(<i>o</i>-aminophenyl)prop-2-ynols with the P(O)–H species: access to C2-phosphorylmethylindoles
Xiaoyan Liu, Yun‐Xiang Zou, Hai‐Liang Ni, Jing Zhang, Hongbo Dong, Long Chen
Abstract
A novel method to synthesize C2-phosphorylmethylindoles <italic>via</italic> the carbocation formation initiated tandem phosphorylative allenylation/cyclization of 1-(<italic>o</italic>-aminophenyl)prop-2-ynols with the P(O)–H species has been developed.
Topics & Concepts
TandemChemistryCarbocationCatalysisCombinatorial chemistryMedicinal chemistryStereochemistryOrganic chemistryMaterials scienceComposite materialCatalytic C–H Functionalization MethodsCatalytic Alkyne ReactionsOrganophosphorus compounds synthesis