Simultaneous determination of 11 oral targeted antineoplastic drugs and 2 active metabolites by LC-MS/MS in human plasma and its application to therapeutic drug monitoring in cancer patients
Jing Zhao, Dongming Yan, Yue Li, Xiaoqing Xu, Fengling Li, Shuang Zhang, Jingyi Jin, Furong Qiu
Topics & Concepts
SunitinibLenvatinibRegorafenibSorafenibPharmacologyTherapeutic drug monitoringBioanalysisGefitinibEverolimusChemistryLapatinibActive metaboliteProtein precipitationMedicineChromatographyDrugHepatocellular carcinomaInternal medicineCancerPharmacokineticsBreast cancerColorectal cancerEpidermal growth factor receptorTrastuzumabChronic Myeloid Leukemia TreatmentsChronic Lymphocytic Leukemia ResearchPI3K/AKT/mTOR signaling in cancer