Novel alkylaminoethyl derivatives of androstane 3-oximes as anticancer candidates: synthesis and evaluation of cytotoxic effects
Jovana J. Ajduković, Dimitar Jakimov, Lucie Rárová, Miroslav Strnad, Yaraslau Dzichenka, Sergey A. Usanov, Dušan Škorić, Suzana Jovanović-Šanta, Marija N. Sakač
Abstract
investigations against cytochrome P450 enzymes revealed that certain compounds can bind selectively in the active sites of human steroid hydroxylases CYP7, CYP17A1, CYP19A1 or CYP21A2, which could be important for the development of novel activity modulators of these enzymes and identification of possible side effects.
Topics & Concepts
Cytotoxic T cellChemistryCytotoxicityCell cultureIn vitroSteroidA549 cellCancer researchCancer cellBiochemistryStereochemistryCancerBiologyInternal medicineMedicineHormoneGeneticsEstrogen and related hormone effectsSteroid Chemistry and BiochemistryInflammatory mediators and NSAID effects