DNA‐Inspired Multi‐Functional Double‐Cross‐Linking Self‐Healing Hydrogel Promotes the Healing of Diabetic Wounds
Yang Pu, Yue Hu, Yikun Ju, Nancy Hsiung, Juyi Ye, Anquan Jian, Lanjie Lei, Bairong Fang
Abstract
Abstract The impaired healing of diabetic wounds caused by microenvironmental imbalances presents a significant clinical challenge. In this study, a deoxyribonucleic acid (DNA)‐inspired, self‐healing hydrogel‐based delivery system—ATG@Exo Cur —is developed that synergistically promotes diabetic wound healing by modulating multiple pathological processes. This system features a double‐crosslinked, self‐healing hydrogel derived from natural polysaccharides, which leverages the principle of DNA base‐pairing to achieve controlled drug release and mechanical adaptability. Additionally, incorporating exosome‐loaded curcumin enhances its physicochemical stability and improves the targeted delivery efficiency. This study demonstrates that ATG@Exo Cur effectively scavenges reactive oxygen species, suppresses chronic inflammation, promotes angiogenesis, and modulates the immune microenvironment by inducing macrophage polarization toward a pro‐repair phenotype. By integrating biomaterial engineering with biological activity, this system overcomes the limitations of monotherapies and offers a novel, highly efficient, and safe approach for treating chronic diabetic wounds.