A hypoxia-dissociable siRNA nanoplatform for synergistically enhanced chemo-radiotherapy of glioblastoma
Yandong Xie, Xueying Lü, Zhen Wang, Mingxi Liu, Liang Liu, Ran Wang, Kun Yang, Hong Xiao, Jianyong Li, Xianglong Tang, Hongyi Liu
Abstract
experiments showed that RDPP(Met)/TMZ/siMGMT could efficiently penetrate the blood-brain barrier (BBB), accurately target GBM cells and effectively inhibit GBM proliferation. Compared with traditional TMZ combined with RT, RDPP(Met)/TMZ/siMGMT remarkably improved the survival time of orthotopic GBM-bearing mice, which demonstrated that our nanoplatform was an efficient combinatorial GBM therapy.
Topics & Concepts
RadiosensitivityHypoxia (environmental)GlioblastomaRadiation toleranceChemistryCancer researchRadiation therapyLiposomeTumor hypoxiaPharmacologyBiologyMedicineBiochemistryOxygenInternal medicineOrganic chemistryNanoplatforms for cancer theranosticsRNA Interference and Gene DeliveryAdvanced biosensing and bioanalysis techniques