High Intensity Focused Ultrasound-Responsive and Ultrastable Cerasomal Perfluorocarbon Nanodroplets for Alleviating Tumor Multidrug Resistance and Epithelial–Mesenchymal Transition
Xiaotu Ma, Meinan Yao, Jiyun Shi, Xiaoda Li, Yu Gao, Qi Luo, Rui Hou, Xiaolong Liang, Fan Wang
Abstract
+ M-HIFU" was utilized as a neoadjuvant chemotherapy, nanodroplets down-regulated heat shock proteins, reducing tumor relapse after the high-temperature HIFU (H-HIFU)-mediated hyperthermia ablation. The chemo-hyperthermia therapy totally eradicated tumors without any relapse or metastasis, providing a promising way to treat the triple-negative breast cancer, which is highly malignant, easily metastatic, and lacks effective treatments.
Topics & Concepts
High-intensity focused ultrasoundMultiple drug resistanceMesenchymal stem cellCancer researchEpithelial–mesenchymal transitionMaterials scienceNanotechnologyFocused ultrasoundUltrasoundBiomedical engineeringMedicineDrug resistanceChemistryTransition (genetics)PathologyBiologyRadiologyMicrobiologyBiochemistryGeneUltrasound and Hyperthermia ApplicationsNanoplatforms for cancer theranosticsNanoparticle-Based Drug Delivery