One-pot three-component tandem annulation of 4-hydroxycoumarine with aldehyde and aromatic amines using graphene oxide as an efficient catalyst
Rabindranath Singha, Aminul Islam, Pranab Ghosh
Abstract
A convenient and efficient solvent-free, facile, one-pot three-component graphene oxide catalysed approach has been described for the synthesis of chromeno-[4,3-b]quinolin-6-one derivatives from 4-hydroxycoumarin with aldehydes and aromatic amines. Graphene oxide (GO) has proved to be a new class of heterogeneous carbocatalyst which could be easily recovered and reused up to 5th run without significant loss of its catalytic activity. A broad scope of substrate applicability is offered and a plausible mechanism is also suggested for this developed protocol.
Topics & Concepts
GrapheneTandemCatalysisOxideAldehydeAnnulationCombinatorial chemistryChemistrySubstrate (aquarium)Component (thermodynamics)Scope (computer science)SolventOrganic chemistryComputer scienceMaterials scienceNanotechnologyThermodynamicsProgramming languageComposite materialOceanographyPhysicsGeologyMulticomponent Synthesis of HeterocyclesSynthesis and Biological EvaluationNanomaterials for catalytic reactions