Albendazole solid dispersions prepared using PEG6000 and Poloxamer188: formulation, characterization and <i>in vivo</i> evaluation
Chun-Liu Dong, Sidi Zheng, Yanyan Liu, Wenqiang Cui, Mei-Qi Hao, God’spower Bello-Onaghise, Xueying Chen, Yan-Hua Li
Abstract
pharmacokinetic study was conducted in beagle dogs. As a result, ABZ solid dispersion based on PEG 6000&P 188 (1:2) was successfully prepared. The ABZ-SD formulation could significantly improve the apparent solubility and dissolution rate of ABZ compared with commercial tablets. Furthermore, the water solubility of ABZ-SD was improved mainly based on hydrogen bond association. Besides, at an oral dosage of 15 mg/kg ABZ, the SDs had higher Cmax values and areas under the curve (AUCs) compared to those of commercial ABZ tablets. Preparation of ABZ-loaded SDs by PEG 6000&P 188 is a promising strategy to improve the oral bioavailability of ABZ.