5-Aza-4′-thio-2′-deoxycytidine, a New Orally Bioavailable Nontoxic “Best-in-Class”: DNA Methyltransferase 1–Depleting Agent in Clinical Development

William B. Parker, Jaideep V. Thottassery

2021Journal of Pharmacology and Experimental Therapeutics23 citationsDOI Open Access PDF

Topics & Concepts

DecitabineDNA methyltransferaseAzacitidineDNMT1MethyltransferasePharmacologyDeoxycytidineChemistryDNA methylationBiochemistryBiologyMethylationDNACancerGeneticsGene expressionGeneGemcitabineEpigenetics and DNA MethylationAcute Lymphoblastic Leukemia researchHemoglobinopathies and Related Disorders