Design and synthesis of novel quinazolinone–chalcone hybrids as potential apoptotic candidates targeting caspase-3 and PARP-1:<i>in vitro</i>, molecular docking, and SAR studies
Eman A. Madbouly, El‐Sayed M. Lashine, Ahmed A. Al‐Karmalawy, Mahmoud M. Sebaiy, Harris Pratsinis, Dimitris Kletsas, Kamel Metwally
Abstract
Novel quinazolinone–chalcone hybrids as potential apoptotic candidates targeting caspase-3 and PARP-1.
Topics & Concepts
ChemistryChalconeQuinazolinoneIn vitroPoly ADP ribose polymeraseApoptosisCaspase 3Combinatorial chemistryStereochemistryBiochemistryDNAProgrammed cell deathPolymeraseCell death mechanisms and regulationPARP inhibition in cancer therapyCancer therapeutics and mechanisms