Draft Genome Sequences of 15 Bacterial Species Constituting the Stable Defined Intestinal Microbiota of the GM15 Gnotobiotic Mouse Model
Céline Elie, Alban Mathieu, Adrien Saliou, Adrien Villain, Marion Darnaud, François Leulier, Andrea Tamellini
Abstract
The GM15 community is a bacterial consortium used to generate a novel standardized mouse model with a simplified controlled intestinal microbiota recapitulating the specific opportunistic pathogen-free (SOPF) mouse phenotype and the potential to ensure an increased reproducibility and robustness of preclinical studies by limiting the confounding effect of microbiota composition fluctuation.
Topics & Concepts
BiologyLimitingMicrobiologyPhenotypeGenomeRobustness (evolution)BacteriaComputational biologyGeneticsGeneMechanical engineeringEngineeringGut microbiota and healthClostridium difficile and Clostridium perfringens researchProbiotics and Fermented Foods