Facile synthesis of axially chiral styrene-type carboxylic acids <i>via</i> palladium-catalyzed asymmetric C–H activation
Chi Yang, Tian-Rui Wu, Yan Li, Bingbing Wu, Ruo‐Xing Jin, Duo‐Duo Hu, Yuanbo Li, Kang‐Jie Bian, Xi‐Sheng Wang
Abstract
Palladium-catalyzed asymmetric C–H functionalization to yield axially chiral styrene-type carboxylic acids is described, in which axial chirality and sterically hindered group were incorporated in one-step.
Topics & Concepts
PalladiumStyreneSteric effectsChirality (physics)CatalysisChemistryYield (engineering)Axial symmetrySurface modificationCarboxylic acidPolymer chemistryOrganic chemistryMaterials scienceCopolymerChiral symmetryPhysicsPolymerPhysical chemistryQuantum mechanicsQuarkNambu–Jona-Lasinio modelMetallurgyAxial and Atropisomeric Chirality SynthesisCatalytic C–H Functionalization MethodsAlkaloids: synthesis and pharmacology