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SIRT6 controls hepatic lipogenesis by suppressing LXR, ChREBP, and SREBP1

Chaoyu Zhu, Menghao Huang, Hyeong-Geug Kim, Kushan Chowdhury, Jing Gao, Sheng Liu, Jun Wan, Wei Li, X. Charlie Dong

2021Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease45 citationsDOIOpen Access PDF

Topics & Concepts

Carbohydrate-responsive element-binding proteinLipogenesisSterol regulatory element-binding proteinFatty liverLiver X receptorBiologyKnockout mouseSirtuinLipid metabolismInternal medicineEndocrinologyNAD+ kinaseBiochemistryTranscription factorNuclear receptorReceptorCholesterolMedicineGeneSterolDiseaseEnzymeCholesterol and Lipid MetabolismLiver Disease Diagnosis and TreatmentDiet, Metabolism, and Disease
SIRT6 controls hepatic lipogenesis by suppressing LXR, ChREBP, and SREBP1 | Litcius