Cancer cell-selective modulation of mitochondrial respiration and metabolism by potent organogold(<scp>iii</scp>) dithiocarbamates
R. Tyler Mertens, Sean Parkin, Samuel G. Awuah
Abstract
irreversibly and rapidly inhibits maximal respiration in TNBC with no effect on normal epithelial cells, implicating mitochondrial OXPHOS as a potential target. Furthermore, the modulation of cyclin dependent kinases and G1 cell cycle arrest induced by these compounds is promising for the treatment of cancer. This work contributes to the need for mitochondrial respiration modulators in biomedical research and outlines a systematic approach to study the mechanism of action of metal-based agents.
Topics & Concepts
RespirationChemistryMetabolismMitochondrionCancerModulation (music)Cellular respirationCellBiochemistryBiologyBotanyGeneticsAestheticsPhilosophyOrganometallic Compounds Synthesis and CharacterizationSynthesis and Characterization of Heterocyclic CompoundsBone health and treatments