Cancer cell intrinsic TIM-3 induces glioblastoma progression
Qing Guo, Shuai Shen, Gefei Guan, Chen Zhu, Cunyi Zou, Jingyuan Cao, Wen Cheng, Xiaoyan Xu, Juan‐Han Yu, Zhiguo Lin, Guoli Wang, Ling Chen, Peng Cheng, Anhua Wu
Abstract
. Our work identifies glioma cell-intrinsic functions of TIM-3/IL6 signal mediating the crosstalk feedback loop between glioma cells and tumor-associated macrophages (TAMs). Blocking this feedback loop may provide a novel therapeutic strategy for GBM.
Topics & Concepts
GliomaCrosstalkCancer researchImmune systemTumor microenvironmentSignal transductionTumor progressionBiologyChemistryCancerCell biologyImmunologyGeneticsOpticsPhysicsGalectins and Cancer BiologySignaling Pathways in DiseaseMacrophage Migration Inhibitory Factor