Recent Advances in Transition Metal Catalyzed Synthesis of <i>β</i> ‐Enaminones and <i>β</i> ‐Enaminoesters
Yeming Wang, Chaoqun Zhang, Shizhe Li, Lihui Liu, Xiaodong Feng
Abstract
Abstract β ‐Enaminones and β ‐enaminoesters are reactive and versatile building blocks in organic synthesis. The favorable structure of electron‐withdrawing carbonyl group or ester group and electron‐donating amino groups are respectively linked at both termini of a C=C double bond. In recent years, transition metal catalyzed synthesis of β‐ enaminones and β ‐enaminoesters have been widely explored and continuously reported. Thus, herein we intended to review the progress in transition metal catalytic routes to these useful synthetic intermediates, with a sequence of condensation of amines with β ‐dicarbonyl compounds, aldol‐type addition of ketones to nitriles, N−H olefination of amines and sulfonamides, amination of propargyl alcohols and ynones, multi‐component reactions, and other reactions.