Discovery of novel PARP/PI3K dual inhibitors with high efficiency against BRCA-proficient triple negative breast cancer
Junwei Wang, Guangchao He, Hui Li, Yiran Ge, Shuping Wang, Yungen Xu, Qihua Zhu
Topics & Concepts
OlaparibPARP inhibitorTriple-negative breast cancerPI3K/AKT/mTOR pathwayChemistryCancer researchBreast cancerPoly ADP ribose polymerasePharmacologyCancerMedicineApoptosisBiochemistryInternal medicineEnzymePolymerasePARP inhibition in cancer therapyIntegrated Circuits and Semiconductor Failure AnalysisDNA Repair Mechanisms