Discovery of novel quinazoline derivatives as potent PI3Kδ inhibitors with high selectivity
Yu Teng, Xinyu Li, Shengnan Ren, Yu Cheng, Kun Xi, Hongtao Shen, Wenzhuo Ma, Guoshun Luo, Hua Xiang
Topics & Concepts
ChemistryPI3K/AKT/mTOR pathwayQuinazolineSelectivityProtein kinase BEnzymeStructure–activity relationshipLead compoundPharmacologySignal transductionBiochemistryCombinatorial chemistryStereochemistryIn vitroBiologyCatalysisQuinazolinone synthesis and applicationsPI3K/AKT/mTOR signaling in cancerBiochemical and Molecular Research