Return to play after COVID-19: a sport cardiologist’s view
Hélder Dores, Nuno Cardim
Abstract
Wine intake is associated with a better lung function in the general population, yet the source of this effect is unknown. Resveratrol, a polyphenol in wine, has anti-inflammatory properties in the lung, its effects being partially mediated <i>via</i> induction of Sirtuin (SIRT)1 activity. We assessed the impact of wine and resveratrol intake, and <i>SIRT1</i> single-nucleotide polymorphisms (SNPs) on lung function in the general population. Effects of red and white wine and resveratrol intake on forced expiratory volume in 1 s (FEV<sub>1</sub>), forced vital capacity (FVC) and FEV<sub>1</sub>/FVC were analysed in the population-based Doetinchem cohort (n=3,224). Associations of four tagging <i>SIRT1</i> SNPs with lung function were analysed in the Doetinchem (n=1,152) and Vlagtwedde–Vlaardingen (n=1,390) cohorts. Resveratrol intake was associated with higher FVC levels, and white wine intake with higher FEV<sub>1</sub> levels and lower risk of airway obstruction. <i>SIRT1</i> SNPs were not significantly associated with level or course of lung function, either directly or indirectly <i>via</i> wine or resveratrol intake. This study shows a positive association of resveratrol intake with lung function in the general population, confirms the previously reported positive association of white wine intake with higher levels of FEV<sub>1</sub>, and additionally shows an association with a higher FEV<sub>1</sub>/FVC ratio. These effects probably do not run <i>via</i> SNPs in <i>SIRT1</i>.