Dissolving microneedles for transdermal delivery of huperzine A for the treatment of Alzheimer's disease
Qinying Yan, Weiwei Wang, Jiaqi Weng, Zhenghan Zhang, Lina Yin, Qingliang Yang, Fangyuan Guo, Xingang Wang, Fan Chen, Gensheng Yang
Abstract
(twofold), compared with the oral group at the same dose of Hup A. Pharmacodynamic research showed a significant improvement in cognitive function in AD rats treated with DMNP-Hup A and Oral-Hup A, as compared to the model group without treatment. Those results demonstrated that this predesigned DMNP is a promising alternative to deliver Hup A transdermally for the treatment of AD.
Topics & Concepts
TransdermalHuperzine AMaterials scienceTransdermal patchDissolutionDrug deliveryPharmacologyMedicineNanotechnologyChemistryOrganic chemistryAcetylcholinesteraseEnzymeAdvancements in Transdermal Drug DeliveryAdvanced Drug Delivery SystemsBee Products Chemical Analysis