Organocatalytic enantioselective S<sub>N</sub>1-type dehydrative nucleophilic substitution: access to bis(indolyl)methanes bearing quaternary carbon stereocenters
Wen-Run Zhu, Qiong Su, Xiaoyi Deng, Jiasheng Liu, Tao Zhong, Shan‐Shui Meng, Ji-Tao Yi, Jiang Weng, Gui Lu
Abstract
A highly general and straightforward approach to access chiral bis(indolyl)methanes (BIMs) bearing quaternary stereocenters has been realized via enantioconvergent dehydrative nucleophilic substitution.
Topics & Concepts
StereocenterEnantioselective synthesisSubstitution (logic)ChemistryNucleophilic substitutionNucleophileQuaternary carbonMedicinal chemistryCarbon fibersStereochemistryOrganic chemistryCatalysisMathematicsComputer scienceComposite numberAlgorithmProgramming languageSynthesis of Indole DerivativesAsymmetric Synthesis and CatalysisAxial and Atropisomeric Chirality Synthesis